"...During development, the nervous system forms as a
flat sheet called the neuroepithelium on the outer layer of the embryo.
This sheet eventually folds in on itself to form a neural tube that
gives rise to the brain and spinal cord—a process that involves the
proliferation and migration of immature nerve cells to form the brain at
one end and the spinal cord at the other. Yoshiki Sasai, Taisuke
Kadoshima and colleagues from the RIKEN Center for Developmental Biology
have now shown that human embryonic stem (ES) cells can spontaneously
organize into the cerebral cortical tissue that forms at the front, or
‘brain’ end, of the developing neural tube1. .."
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